Endocrine Abstracts

Glucocorticoid hormones (GCs) remain the mainstay for the treatment of various inflammatory disorders, because of their great efficacy. The long-term usage of GCs is, however, overshadowed by the occurrence of debilitating side-effects, like osteoporosis, skin and muscle atrophy, diabetes and neurological disorders. GCs exert their functions through binding to the glucocorticoid receptor (GR), a transcription factor that regulates gene transcription in a positive or negative w...